The Chemical Chaperone 4-Phenylbutyric Acid Prevents Alcohol-Induced Liver Injury in Obese KK-Ay Mice.
Maiko SuzukiKazuyoshi KonKenichi IkejimaKumiko AraiAkira UchiyamaTomonori AoyamaShunhei YamashinaTakashi UenoSumio WatanabePublished in: Alcoholism, clinical and experimental research (2019)
Binge EtOH intake after chronic consumption induces massive ER stress-related oxidative stress and liver injury in a mouse model of obesity through dysregulation of the unfolded protein response. PBA ameliorated chronic-plus-binge EtOH-induced liver injury by reducing ER and oxidative stress after an EtOH binge.
Keyphrases
- drug induced
- liver injury
- oxidative stress
- mouse model
- diabetic rats
- weight loss
- metabolic syndrome
- high fat diet induced
- endoplasmic reticulum
- type diabetes
- dna damage
- insulin resistance
- adipose tissue
- ischemia reperfusion injury
- weight gain
- induced apoptosis
- heat shock
- bariatric surgery
- high glucose
- body mass index
- estrogen receptor
- skeletal muscle
- signaling pathway
- small molecule
- amino acid
- endothelial cells
- breast cancer cells
- heat shock protein