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Dose-related Mutagenic and Clastogenic Effects of Benzo[b]fluoranthene in Mouse Somatic Tissues Detected by Duplex Sequencing and the Micronucleus Assay.

David M SchusterD P M LeBlancG ZhouM J MeierA E DodgeP A WhiteA S LongA WilliamsC HobbsA DiesingStephanie L Smith-RoeJesse J SalkF MarchettiC L Yauk
Published in: bioRxiv : the preprint server for biology (2024)
]fluoranthene across the mouse genome. Dose-dependent changes in mutation frequency and spectrum quantify its role in PAH-induced carcinogenicity.
Keyphrases
  • high glucose
  • gene expression
  • high throughput
  • diabetic rats
  • drug induced
  • single cell
  • copy number
  • genome wide
  • oxidative stress
  • dna methylation
  • endothelial cells