Breast cancer patient-derived organoids for the investigation of patient-specific tumour evolution.

Serena Mazzucchelli Lorena Signati Letizia Messa Alma Franceschini Arianna Bonizzi Lorenzo Castagnoli Patrizia Gasparini Clarissa Consolandi Eleonora Mangano Paride Pelucchi Ingrid Cifola Tania Camboni Marco Severgnini Laura Villani Barbara Tagliaferri Stephana Carelli Serenella Maria Pupa Cristina Cereda Fabio Corsi

Published in: Cancer cell international (2024)

Neoadjuvant treatment contributed to the enrichment of cell populations with luminal phenotypes that were more resistant to chemotherapy in O-POST. PDOs represent an excellent 3D cell model for assessing disease evolution.

Keyphrases

single cell
cell therapy
locally advanced
rectal cancer
lymph node
squamous cell carcinoma
stem cells