Neuroinflammation trajectories precede cognitive impairment after experimental meningitis-evidence from an in vivo PET study.

Vijayasree V GiridharanAllan CollodelJaqueline S GenerosoGiselli ScainiRico WassatherSudhakar SelvarajRodrigo HasbunFelipe Dal-PizzolFabricia PetronilhoTatiana Barichello

Published in: Journal of neuroinflammation (2020)

TSPO-PET could potentially be used as an imaging biomarker for microglial activation and long-term cognitive impairment post-meningitis. Additionally, this study opens a new avenue for the potential use of TSPO ligands after infection-induced neurological sequelae.

Keyphrases

cognitive impairment
pet imaging
computed tomography
lipopolysaccharide induced
inflammatory response
depressive symptoms
lps induced
spinal cord
risk assessment
drug induced
diabetic rats
blood brain barrier
high glucose
climate change
human health