Serum succinate/fumarate ratio in paraganglioma/pheochromocytoma patients attending an endocrine oncogenetic unit.

Léo-Paul BancelVincent MassoAnne-Frederique DesseinSébastien AubertEmmanuelle LeteurtreLucie CoppinMarie-Françoise OdouChristine Do CaoCatherine Cardot-BautersPascal Pigny

Published in: The Journal of clinical endocrinology and metabolism (2023)

Measurement of serum RS/F in PPGL patients and in asymptomatic relatives is a valuable initial workup tool to detect those carrying a germline PV/LPV in SDHx. Its discriminative power is equal to superior to those of succinate measured alone. SDHD PV/LPV are less frequently identified by these biochemical tools. Use of RS/F for SDHx VUS reclassification needs to be further evaluated.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
patient reported outcomes
dna repair
patient reported
tertiary care