CSF chitinases before and after symptom onset in amyotrophic lateral sclerosis.

Elizabeth GrayAlexander Guy ThompsonJoanne WuuJoe PeltKevin TalbotMichael Benatar Matthew C Kiernan

Published in: Annals of clinical and translational neurology (2020)

The CHIT1 neuroinflammatory response is a feature of the late presymptomatic to early symptomatic phases of ALS. This study does not suggest a long prodrome of upregulated glial activity in ALS pathogenesis, but strengthens the place of CHIT1 as part of a panel of biomarkers to objectively assess the impact of immune-modulatory therapeutic interventions in ALS.

Keyphrases

amyotrophic lateral sclerosis
physical activity
machine learning
deep learning
spinal cord
patient reported