The first 142 amino acids of glutamate decarboxylase do not contribute to epitopes recognized by autoantibodies associated with Type 1 diabetes.
R C WyattC BrigattiD LiberatiS L GraceB T GillardA E LongI MarzinottoD K ShoemarkK A ChandlerP AchenbachK M GillespieL PiemontiV LampasonaAlistair J K WilliamsPublished in: Diabetic medicine : a journal of the British Diabetic Association (2018)
The first 142 amino acids of GAD65 do not contribute to epitopes recognized by Type 1 diabetes-associated GAD antibodies. Low-volume radioimmunoassays using N-terminally truncated 35 S-GAD65 are more specific than those using full-length GAD65 and offer practical alternatives to the GAD antibody ELISA for identifying children at increased risk of Type 1 diabetes.