A photo-activated aptamer-drug conjugate for targeted drug delivery.
Jing LiuXiangjun LiuMengwen YiYue SunTao BingNan ZhangDihua ShangguanPublished in: Chemical communications (Cambridge, England) (2022)
A photo-activated aptamer-drug conjugate, HG1-9-DNP, was developed based on an aptamer HG1-9 and a photolabile naphthalimide derivative DNP. HG1-9-DNP could be internalized into cells mediated by TfR, then photocleaved, and released a promising cytotoxic agent, DNNH, which arrested the cell cycle at the G2/M phase, resulting in high photo-induced cytotoxicity.
Keyphrases
- cell cycle
- cancer therapy
- fluorescent probe
- drug delivery
- gold nanoparticles
- sensitive detection
- living cells
- magnetic nanoparticles
- cell proliferation
- induced apoptosis
- drug induced
- label free
- aqueous solution
- electron transfer
- cell cycle arrest
- diabetic rats
- adverse drug
- emergency department
- cell death
- signaling pathway
- endoplasmic reticulum stress
- endothelial cells
- single molecule