An oral phenylacrylic acid derivative suppressed hepatic stellate cell activation and ameliorated liver fibrosis by blocking TGF-β1 signaling.

Taixiong XueLin YueGuonian ZhuZui TanHongyao LiuCailing GanChen FanXingping SuYuting XieTinghong Ye

Published in: Liver international : official journal of the International Association for the Study of the Liver (2022)

we reported an oral phenylacrylic acid derivative, FA11, which showed excellent antifibrotic activity and was expected to be an anti-hepatic fibrosis candidate.

Keyphrases

liver fibrosis
single cell
cell therapy
transforming growth factor
stem cells
signaling pathway