Recently, nanomedicine design has shifted from simple nanocarriers to nanodrugs with intrinsic antineoplastic activities for therapeutic performance optimization. In this regard, degradable nanomedicines containing functional inorganic ions have blazed a highly efficient and relatively safe ion interference paradigm for cancer theranostics. Herein, given the potential superiorities of infinite coordination polymers (ICPs) in degradation peculiarity and functional integration, a state-of-the-art dual-ICP-engineered nanomedicine is elaborately fabricated via integrating ferrocene (Fc) ICPs and calcium-tannic acid (Ca-TA) ICPs. Thereinto, Fc ICPs, and Ca-TA ICPs respectively serve as suppliers of ferrous iron ions (Fe 2+ ) and calcium ions (Ca 2+ ). After the acid-responsive degradation of ICPs, released TA from Ca-TA ICPs facilitated the conversion of released ferric iron (Fe 3+ ) from Fc ICPs into highly active Fe 2+ . Owing to the dual-path oxidative stress and neighboring effect mediated by Fe 2+ and Ca 2+ , such a dual-ICP-engineered nanomedicine effectively induces dual-ion interference against triple-negative breast cancer (TNBC). Therefore, this work provides a novel antineoplastic attempt to establish ICP-engineered nanomedicines and implement ion interference-mediated synergistic therapy.
Keyphrases
- oxidative stress
- cancer therapy
- highly efficient
- aqueous solution
- quantum dots
- drug delivery
- protein kinase
- dna damage
- young adults
- risk assessment
- metal organic framework
- ischemia reperfusion injury
- stem cells
- mesenchymal stem cells
- diabetic rats
- water soluble
- induced apoptosis
- bone marrow
- endoplasmic reticulum stress
- human health
- climate change
- heat shock
- cell therapy