Absolute CD4+ T cell count overstate immune recovery assessed by CD4+/CD8+ ratio in HIV-infected patients on treatment.

Yusnelkis Milanés-GuisadoAlicia Gutiérrez-ValenciaMaría Trujillo-RodríguezNuria EspinosaPompeyo VicianaLuis Fernando López-Cortés

Published in: PloS one (2018)

The increases in aCD4 poorly correlate with those of CD4% and CD4/CD8. IR rates based on aCD4 significantly overstate those obtained by CD4% and CD4/CD8. CD4% and CD4/CD8 are more stable markers than aCD4 and should be taken into account to monitor the IR after treatment initiation.

Keyphrases

hiv infected patients
nk cells
peripheral blood
combination therapy
replacement therapy