Probabilistic sweet spots predict motor outcome for deep brain stimulation in Parkinson disease.
Till A DembekJan RoedigerChristos GanosPaul RekerCarina OehrnHaidar Salimi DafsariNingfei LiAndrea A KühnGereon R FinkVeerle Visser-VandewalleMichael T BarbeLars TimmermannPublished in: Annals of neurology (2020)
This study is the first to predict clinical improvement of parkinsonian motor symptoms across cohorts based on local DBS effects only. The new approach revealed a distinct sweet spot for STN DBS in PD. Stimulation overlap with the sweet spot can predict short- and long-term motor outcome and may be used to guide DBS programming. ANN NEUROL 2019;86:527-538.