Differential effects on neurodevelopment of FTO variants in obesity and bipolar disorder suggested by in silico prediction of functional impact: An analysis in Mexican population.

Erasmo Saucedo-UribeAlma Delia Genis-MendozaAdriana Díaz-AnzaldúaJosé Jaime Martínez-MagañaCarlos Alfonso Tovilla-ZárateIsela Juárez-RojopNuria Lanzagorta-PiñolMichael EscamillaThelma Beatriz González-CastroMaría Lilia López NarvaezYazmín Hernández-DíazHumberto Nicolini

Published in: Brain and behavior (2019)

Our results suggest a possible effect of FTO variants on neurodevelopment in obesity and bipolar disorder, which gives new insights into the molecular mechanism underlying this association.

Keyphrases

bipolar disorder
major depressive disorder
insulin resistance
metabolic syndrome
weight loss
copy number
high fat diet induced
type diabetes
weight gain
molecular docking
adipose tissue
gene expression
dna methylation
physical activity