Age-dependent bone loss and recovery during hindlimb unloading and subsequent reloading in rats.
Hailey C CunninghamDaniel W D WestLeslie M BaehrFranklin D TarkeKeith BaarSue C BodineBlaine A ChristiansenPublished in: BMC musculoskeletal disorders (2018)
These data suggest that aged bone is less responsive to both increased and decreased mechanical loading, and that acute periods of disuse may leave older subjects with a long-term deficit in trabecular bone mass. These finding indicate the need for therapeutic strategies to improve the skeletal health of elderly patients during periods of disuse.
Keyphrases
- bone loss
- bone mineral density
- healthcare
- liver failure
- public health
- postmenopausal women
- physical activity
- electronic health record
- cancer therapy
- body composition
- middle aged
- soft tissue
- intensive care unit
- aortic dissection
- health promotion
- climate change
- social media
- risk assessment
- extracorporeal membrane oxygenation