Mutational Mosaics of Cell-Free DNA from Pancreatic Cyst Fluids.

Agnieszka PaziewskaMarcin PolkowskiKrzysztof GorycaJakub KarczmarskiAnna Wiechowska-KozlowskaMichalina DabrowskaMichal MikulaJerzy Ostrowski

Published in: Digestive diseases and sciences (2020)

We demonstrate relatively high rates of somatic mutations of cancer-related genes, including KRAS and GNAS, in cfDNA isolated from PCFs irrespectively of the pancreatic cyst type. Further studies on molecular mechanisms of pancreatic cysts malignant transformation in relation to their mutational profiles are required.

Keyphrases

papillary thyroid
squamous cell carcinoma
gene expression
copy number
genome wide