Genetic associations of TMEM154, PRC1 and ZFAND6 loci with type 2 diabetes in an endogamous business community of North India.

Gagandeep Kaur WaliaPratiksha SharmaTripti AgarwalMoti LalHimanshu NegandhiDorairaj PrabhakaranRajesh KhadgawatMohinder Pal SachdevaVipin Gupta

Published in: PloS one (2023)

We confirm the role of ZFAND6, PRC1 and TMEM154 in the pathophysiology of type 2 diabetes among Indians. More efforts are needed with larger sample sizes to validate the diabetes GWAS loci in South Asian populations for wider applicability.

Keyphrases

genome wide
genome wide association study
dna methylation
genome wide association
type diabetes
cardiovascular disease
healthcare
mental health
copy number
glycemic control
quality improvement
tertiary care
gene expression
adipose tissue
genetic diversity
skeletal muscle