Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis.
Mika KivimakiArchana Singh-ManouxJaana PenttiSéverine SabiaSolja T NybergLars AlfredssonMarcel GoldbergAnders KnutssonMarkku KoskenvuoAki KoskinenAnne KouvonenMaria NordinTuula OksanenTimo StrandbergSakari B SuominenTöres TheorellJussi VahteraAri VäänänenMarianna VirtanenPeter WesterholmHugo WesterlundMarie ZinsSudha SeshadriG David BattyPyry N SipiläMartin J ShipleyJoni V LindbohmJane E FerrieMarkus Jokelanull nullPublished in: BMJ (Clinical research ed.) (2019)
In analyses that addressed bias due to reverse causation, physical inactivity was not associated with all-cause dementia or Alzheimer's disease, although an indication of excess dementia risk was observed in a subgroup of physically inactive individuals who developed cardiometabolic disease.