Effects of Avitinib on CYP450 Enzyme Activity in vitro and in vivo in Rats.

Yong ShiDeru MengShuanghu WangPeiwu GengTao XuQuan ZhouYunfang ZhouWanshu LiXugao Chen

Published in: Drug design, development and therapy (2021)

A sensitive and reliable UPLC-MS/MS method was established to determine the concentration of six probe substrates in rat plasma. Avitinib had inhibitory effects on CYP450 enzymes, especially cyp2b1, cyp1a2 in RLMs, CYP2C9 in HLMs, and cyp1a2, cyp2b1, cyp2d1, and cyp2e1 in vivo. Our data recommend caution when avitinib was taken simultaneously with drugs metabolized by CYP450 enzymes.

Keyphrases

ms ms
electronic health record
simultaneous determination
big data
high resolution
drug induced
high performance liquid chromatography
fluorescent probe