Genetic Susceptibility Variants of Vascular Dementia among Asians: A Systematic Review and Meta-Analysis.

null Vasudevannull Nur Afiqahnull Mohd NazilW S Wan AliaaI M Liyana Najwanull Mohd Hazminull Siew MooiY K Abdul Hanif Khannull Hamidonnull Pannerselvamnull Suganthinull Narenkumar

Published in: Dementia and geriatric cognitive disorders (2024)

Our findings provide evidence that genetic polymorphisms of the APOE ε4 allele and MTHFR rs1801133 T allele increase the risk of developing VaD in Asians. However, future large-scale investigations examining particularly on South-Eastern and West-Asian populations are highly recommended.

Keyphrases

copy number
mild cognitive impairment
cognitive decline
south africa
current status
genome wide
cognitive impairment
high fat diet
gene expression
adipose tissue
metabolic syndrome
genetic diversity
insulin resistance