A molecular recognition-activatable DNA nanofirecracker enables signal-enhanced imaging in living cells.

Xiaojing XingJin LiLiping Qiu Weihong Tan

Published in: Chemical communications (Cambridge, England) (2020)

We propose an aptamer-tethered DNA nanofirecracker probe that realizes molecular recognition-activatable disassembly of the DNA nanostructure for imaging of target molecules in living cells. The design principle offers a new paradigm to develop nucleic acid nanocircuits for live-cell study and manipulation.

Keyphrases

living cells
single molecule
fluorescent probe
nucleic acid
circulating tumor
high resolution
cell free
fluorescence imaging
photodynamic therapy
magnetic nanoparticles