Combination of Ethacrynic Acid and ATRA Triggers Differentiation and/or Apoptosis of Acute Myeloid Leukemia Cells through ROS.
Lu LiHui-Min XiHao LuXun CaiPublished in: Anti-cancer agents in medicinal chemistry (2024)
EA+ATRA induced cell apoptosis through ROS dependent MMP attenuation and caspase 3/7 activation while inducing differentiation by ROS-MEK/ERK-PU.1/C/EBPs and ROS-Akt-PU.1/C/EBPs pathways. In summary, it may provide innovative ATRA-based combination therapy strategies for AML patients via ROS.
Keyphrases
- cell death
- cell cycle arrest
- acute myeloid leukemia
- reactive oxygen species
- dna damage
- combination therapy
- induced apoptosis
- signaling pathway
- cell proliferation
- end stage renal disease
- pi k akt
- oxidative stress
- ejection fraction
- chronic kidney disease
- newly diagnosed
- endoplasmic reticulum stress
- allogeneic hematopoietic stem cell transplantation
- prognostic factors
- peritoneal dialysis
- high glucose
- patient reported outcomes