The role of plasma neurofilament light chain and glial fibrillary acidic protein in subjective cognitive decline and mild cognitive impairment.
Salvatore MazzeoAssunta IngannatoGiulia GiacomucciSilvia BagnoliArianna CavaliereValentina MoschiniJuri BalestriniCarmen MorinelliGiulia GaldoFilippo EmilianiDiletta PiazzesiChiara CrucittiDaniele FrigerioCristina PolitoValentina BertiSonia PadiglioniSandro SorbiBenedetta NacmiasValentina BessiPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2023)
GFAP exhibited excellent accuracy in distinguishing patients with normal CSF biomarkers from those with prodromal AD. Our results support the use of this peripheral biomarker for detecting AD in patients with subjective and objective cognitive decline.