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RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD.

Jarrett D MorrowRobert P ChaseMargaret M ParkerKimberly GlassMinseok SeoMiguel DivoCaroline A OwenPeter CastaldiDawn L DeMeoEdwin K SilvermanCraig P Hersh
Published in: Respiratory research (2019)
Our integrative analyses across COPD-relevant tissues and prior studies revealed shared and tissue-specific disease biology. These replicated and novel findings in the airway and peripheral blood have highlighted candidate genes and pathways for COPD pathogenesis.
Keyphrases
  • gene expression
  • chronic obstructive pulmonary disease
  • lung function
  • peripheral blood
  • single cell
  • dna methylation
  • genome wide