Serum levels of the IL-6 family of cytokines predict prognosis in renal cell carcinoma (RCC).
Gigja GudbrandsdottirHelene H AarstadLeif BostadKarin M HjelleHans J AarstadØystein BruserudTor Henrik Anderson TvedtChristian BeislandPublished in: Cancer immunology, immunotherapy : CII (2020)
IL-6 and IL-27 seem to play a role in RCC biology. IL-6 enables the pinpointing of metastatic condition at diagnosis, as well as together with IL-27, the predicting of survival and recurrence. Endothelial cells and vascular smooth muscle cells are both suggested as important sources of IL-6.