Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly.
Jordi PeguerolesAdriana PanéEduard VilaplanaVíctor MontalAlexandre BejaninLaura VidelaMaría Carmona-IraguiIsabel BarroetaAinitze IbarzabalAnna CasajoanaDaniel AlcoleaSilvia ValldeneuMiren AltunaAna de HollandaJosep VidalEmilio OrtegaRicardo OsorioAntonio ConvitRafael BlesaAlberto LleóJuan ForteaAmanda Jiméneznull nullPublished in: Alzheimer's & dementia (Amsterdam, Netherlands) (2020)
In the cognitively unimpaired elderly, obesity has differential effects on brain metabolism and structure independent of an underlying AD pathophysiology.
Keyphrases
- insulin resistance
- metabolic syndrome
- weight loss
- resting state
- white matter
- middle aged
- high fat diet induced
- type diabetes
- weight gain
- community dwelling
- functional connectivity
- cerebral ischemia
- adipose tissue
- cognitive decline
- mild cognitive impairment
- body mass index
- physical activity
- cerebrospinal fluid
- blood brain barrier