Pharmacological inhibition of GRK2 improves cardiac metabolism and function in experimental heart failure.
Michele CiccarelliDaniela SorrientoAntonella FiordelisiJessica GambardellaAntonietta FrancoCarmine Del GiudiceMarina SalaMaria Gaia MontiAlessia BertaminoPietro CampigliaMarco OlivetiPoggio PaoloGiovanna TrincheseGina CavaliereErsilia CipollettaMaria Pina MollicaDomenico BonaduceTrimarco BrunoGuido IaccarinoPublished in: ESC heart failure (2020)
GRK2 is a critical molecule in the physiological regulation of cardiac metabolism. Its alterations in the failing heart can be pharmacologically targeted, leading to the correction of metabolic and functional abnormalities observed in HF.