Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation.

Yingjie HuVictor A LopezHengyi XuJames P PfisterBing SongKelly A ServageMasahiro SakuraiBenjamin T JonesJoshua T MendellTao WangJun WuAlan M LambowitzDiana R TomchickKrzysztof PawłowskiVincent S Tagliabracci

Published in: bioRxiv : the preprint server for biology (2024)

and C12orf29 knockout female mice have altered tRNA levels in brain. We also report structures of C12orf29, which have revealed critical insights into the mode of ATP binding and catalysis. Our work suggests that C12orf29 may be a new player in the regulation of tRNAs.

Keyphrases

single cell
high resolution
genome wide
white matter
resting state
wild type
gene expression
dna binding
mass spectrometry
transcription factor