Regiodivergent Synthesis of Densely Functionalized Indolizines via (2 + 2 + 1) Cycloaddition.

Published in: The Journal of organic chemistry (2023)

A novel metal and additive free, atom-economic method for the regiodivergent synthesis of crucial 6- or 8-substituted indolizine from meta -amide-substituted pyridine and alkyne via a [2 + 2 + 1] cycloaddition is developed. The reaction proceeds through the cleavage of the carbon-carbon triple bond. The synthesized product contains an important amide group that can be further functionalized to afford biologically active compounds.

Keyphrases

molecular docking
quantum dots
electron transfer
molecular dynamics
molecularly imprinted
dna binding
transcription factor
molecular dynamics simulations