Evolution and transmission of cefiderocol-resistant Acinetobacter baumannii during an outbreak in the burn intensive care unit.
Steven M SmokeAlison BrophySamuel ReveronAlina IovlevaEllen G KlineMichael MaranoLincoln P MillerRyan K ShieldsPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
We report 11 critically-ill burn patients treated with cefiderocol for carbapenem-resistant Acinetobacter baumannii infections. Clinical success was achieved in 36% and complicated by treatment-emergent resistance and inter-patient transmission of cefiderocol-resistant A. baumannii between patients. Resistant isolates harbored disrupted pirA and piuA genes that were not disrupted among susceptible isolates.
Keyphrases
- acinetobacter baumannii
- multidrug resistant
- gram negative
- drug resistant
- pseudomonas aeruginosa
- intensive care unit
- end stage renal disease
- ejection fraction
- newly diagnosed
- case report
- prognostic factors
- genetic diversity
- cystic fibrosis
- gene expression
- resting state
- genome wide
- mechanical ventilation
- wound healing