Antidepressant alkaloids from the rhizomes of Corydalis decumbens .
Rong-Rui WeiYe TangMao-Hua HeRong-Rui WeiPublished in: Zeitschrift fur Naturforschung. C, Journal of biosciences (2022)
Two new alkaloids ( 1 and 2 ), named 1,7-dimethoxy-2'-prenyl-1',9-dihydropyrrolo-carbazole ( 1 ) and 1,7-dimethoxy-4',5'-dimethylcyclopenta-carbazole-1',3'-dione ( 2 ), along with thirteen known alkaloids ( 3 - 15 ) were isolated by means of silica gel, sephadex LH-20, and semi-preparative HPLC from the CHCl 3 extraction of Corydalis decumbens for the first time. Their structures were determined by NMR, MS, IR, UV, and related references. Compounds ( 1 - 15 ) were evaluated for their antidepressant activities by measuring inhibition of monoamine neurotransmitter reuptake in vitro . Among them, compounds 1 , 2 , 4 , and 6 showed certain antidepressant activities.