Muscarinic receptor 1 allosteric modulators stimulate colorectal emptying in dog, mouse and rat and resolve constipation.

Ruslan V PustovitYasuo ItomiMitchell RinguetShanti DiwakarlaXin-Yi ChaiRachel M McQuadeYasuhiro TsukimiJohn Barton Furness

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2019)

M1PAMs act at targets sites in the colorectum to enhance colorectal propulsion. They are effective across species, and they reverse experimentally induced constipation. Previous studies have shown that they are safe in human. Because they provide an enhancement of physiological control rather than being direct agonists, they are predicted to provide effective treatment for constipation.

Keyphrases

irritable bowel syndrome
small molecule
endothelial cells
high glucose
oxidative stress
diabetic rats
drug induced
case control
combination therapy
stress induced