Distinct Residues Contribute to Motility Repression and Autoregulation in the Proteus mirabilis Fimbria-Associated Transcriptional Regulator AtfJ.
Nadine J BodeKun-Wei ChanXiang-Peng KongMelanie M PearsonPublished in: Journal of bacteriology (2016)
Balancing adherence with motility is essential for uropathogens to successfully establish a foothold in their host. Proteus mirabilis uses a fimbria-associated transcriptional regulator to switch between these antagonistic processes by increasing fimbrial adherence while simultaneously downregulating flagella. The discovery of multiple related proteins, many of which also function as motility repressors, encoded in the P. mirabilis genome has raised considerable interest as to their functionality and potential redundancy in this organism. This study provides an important advance in this field by elucidating the nonidentical effects of these paralogs on a molecular level. Our mechanistic studies of one member of this group, AtfJ, shed light on how these differing functions may be conferred despite the limited sequence variety exhibited by the paralogous proteins.
Keyphrases
- transcription factor
- biofilm formation
- gene expression
- small molecule
- pseudomonas aeruginosa
- staphylococcus aureus
- type diabetes
- escherichia coli
- heat shock
- high throughput
- glycemic control
- genome wide
- dna methylation
- adipose tissue
- human health
- risk assessment
- skeletal muscle
- insulin resistance
- single molecule
- climate change