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Limb Amputation after Multiple Treatments of Tenosynovial Giant Cell Tumour: Series of 4 Dutch Cases.

Monique Josephine MastboomFloortje G M VerspoorAndré B P van KuilenburgMichiel A J van de Sande
Published in: Case reports in orthopedics (2017)
In Tenosynovial Giant Cell Tumours (TGCT), previously named Pigmented Villonodular Synovitis (PVNS), a distinction is made between a single nodule (localized-type) and multiple nodules (diffuse-type). Diffuse-type is considered locally aggressive. Onset and extermination of this orphan disease remain unclear. Surgical resection is the most commonly performed treatment. Unfortunately, recurrences often occur (up to 92%), necessitating reoperations and adjuvant treatments. Once all treatments fail or if severe complications occur, limb amputation may become unavoidable. We describe four cases of above-knee amputation after TGCT diagnosis.
Keyphrases
  • giant cell
  • lower limb
  • peripheral artery disease
  • low grade
  • early stage
  • total knee arthroplasty
  • knee osteoarthritis
  • basal cell carcinoma