Absorption, Distribution, Metabolism, and Excretion of the Androgen Receptor Inhibitor Enzalutamide in Rats and Dogs.
Yoshiaki OhtsuJacqueline A GibbonsKatsuhiro SuzukiMichael E FitzsimmonsKohei NozawaHiroshi AraiPublished in: European journal of drug metabolism and pharmacokinetics (2018)
Rapid oral absorption was observed in rats and dogs when 14C-enzalutamide was administered as Labrasol solution. Tissue distribution in rats was clarified. The elimination of enzalutamide is mediated primarily by metabolism. Species differences were observed in excretion route.
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