Autoantibodies targeting cytokines and connective tissue disease autoantigens are common in acute non-SARS-CoV-2 infections.
Allan FengEmily YangAndrew R MooreShaurya DhingraSarah ChangXihui YinRuoxi PiElisabeth K M MackSara VölkelReinhard GeßnerMargrit GundischAndreas NeubauerHarald RenzSotirios TsiodrasParaskevi FragkouAdijat AsuniJoseph LevittJennifer WilsonMichelle LeongJennifer LumbRong MaoKassandra PinedoJonasel A RoqueChristopher RichardsMikayla StabileGayathri SwaminathanMaria SalagianniVasiliki TriantafylliaWilhelm BertramsCatherine A BlishJan E CaretteJennifer FrankovichEric MeffreKari Christine NadeauUpinder SinghTaia T WangEline T Luning PrakSusanne HeroldEvangelos AndreakosBernd SchmeckChrysanthi SkevakiAngela J RogersPaul J UtzPublished in: Research square (2022)
The widespread presence of autoantibodies in acute infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is increasingly recognized, but the prevalence of autoantibodies in infections with organisms other than SARS-CoV-2 has not yet been reported. We used protein arrays to profile IgG autoantibodies from 317 samples from 268 patients across a spectrum of non-SARS-CoV-2 infections, many of whom were critically ill with pneumonia. Anti-cytokine antibodies (ACA) were identified in > 50% of patients infected with non-SARS-CoV-2 viruses and other pathogens, including patients with pneumonia attributed to bacterial causes. In cell-based functional assays, some ACA blocked binding to surface receptors for type I interferons (Type I IFN), granulocyte-macrophage colony-stimulating factor (GM-CSF), and interleukin-6 (IL-6). Autoantibodies against traditional autoantigens associated with connective tissue diseases (CTDs) were also commonly observed in these cohorts, including newly-detected antibodies that emerged in longitudinal samples from patients infected with influenza. We conclude that autoantibodies, some of which are functionally active, may be much more prevalent than previously appreciated in patients who are symptomatically infected with diverse pathogens.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- end stage renal disease
- systemic lupus erythematosus
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- healthcare
- risk factors
- adipose tissue
- liver failure
- coronavirus disease
- hepatitis b virus
- high throughput
- acute respiratory distress syndrome
- peripheral blood
- bone marrow
- mechanical ventilation
- multidrug resistant
- cell therapy
- extracorporeal membrane oxygenation