Contribution of Trough Concentration Data in the Evaluation of Multiple-Dose Pharmacokinetics for Drugs with Delayed Distributional Equilibrium and Long Half-Life.
Suein ChoiSangil JeonDong-Seok YimSeunghoon HanPublished in: Drug design, development and therapy (2020)
In multiple-dose studies on drugs with delayed distributional equilibrium, information from a few trough samples can augment the limit of serial sampling within the dosing interval for parameter estimation. With informative trough samples, extended hospitalization for serial sampling (until 3-5 half-lives after the last dose), which is particularly problematic for long half-life drugs, may be avoided. Trough samples obtained at the beginning of the repeated dose were more effective for mixed-effects modeling.