Transcription factor NKX2-1 drives serine and glycine synthesis addiction in cancer.

Elien HeylenPaulien VerstraeteLinde Van AerschotShauni L GeeraertsTom VenkenKalina TimchevaDavid NittnerJelle VerbeeckJonathan RoyaertMarion GijbelsAnne UyttebroeckHeidi Segers Diether LambrechtsJan CoolsKim De Keersmaecker Kim Rosalie Kampen

Published in: British journal of cancer (2023)

Collectively, we identify NKX2-1 as a novel transcriptional regulator of serine/glycine synthesis addiction across cancers, revealing a therapeutic vulnerability of NKX2-1-driven cancers. Transcription factor NKX2-1 fuels cancer cell proliferation and survival by hyperactivating serine/glycine synthesis, highlighting this pathway as a novel therapeutic target in NKX2-1-positive cancers.

Keyphrases

transcription factor
papillary thyroid
cell proliferation
squamous cell
childhood cancer
protein kinase
dna binding
climate change
cell cycle
lymph node metastasis
squamous cell carcinoma
young adults
genome wide identification
oxidative stress