Clonal Hematopoiesis and Clinical Outcomes in Metastatic Castration-Resistant Prostate Cancer Patients Given Androgen Receptor Pathway Inhibitors (Alliance A031201).

Jeffrey L Jensen Olivia Bobek Irenaeus C C Chan Brian C Miller David W Hillman Glenn Heller Todd E Druley Andrew J Armstrong Michael J Morris Matthew I Milowsky Himisha Beltran Kelly L Bolton Catherine C Coombs

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

CH did not affect survival in patients with mCRPC treated with ARPIs in A031201. H-CH and TET2-mutated CH were associated with more CVAEs. These findings inform the risk/benefit discussion about ARPIs in mCRPC.

Keyphrases

end stage renal disease
room temperature
newly diagnosed
ejection fraction
small cell lung cancer
squamous cell carcinoma
chronic kidney disease
peritoneal dialysis