Dynamics of leukocyte telomere length in pregnant women living with HIV, and HIV-negative pregnant women: A longitudinal observational study.
Sara SaberiSteve E KallogerMayanne M T ZhuBeheroze SatthaEvelyn J MaanJulianne van SchalkwykDeborah M MoneyHélène C F Côténull nullPublished in: PloS one (2019)
LTL increases as pregnancy progresses; the reasons for this are unknown but may relate to changes in blood volume, hormones, and/or cell subset distribution. While our observations need confirmation in an independent cohort, our data suggest that although some cART regimens may influence LTL, being on cART appears overall protective and that stopping cART post-partum may negatively impact LTL. The effect of smoking on LTL is clearly negative, stressing the importance of smoking cessation.
Keyphrases
- smoking cessation
- pregnant women
- pregnancy outcomes
- replacement therapy
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hepatitis c virus
- single cell
- hiv aids
- hiv testing
- electronic health record
- preterm birth
- cell therapy
- big data
- machine learning
- stem cells
- men who have sex with men
- bone marrow
- south africa