Retinal ganglion cell loss in neuromyelitis optica: a longitudinal study.

Frederike Cosima OertelJoachim HavlaAdriana Roca-FernándezNathaniel LizakHanna ZimmermannSeyedamirhosein MotamediNadja BorisowOwen B WhiteJudith Bellmann-StroblPhilipp AlbrechtKlemens RuprechtSven JariusJacqueline PalaceMaria Isabel LeiteTania KuempfelFriedemann PaulAlexander U Brandt

Published in: Journal of neurology, neurosurgery, and psychiatry (2018)

This study clearly shows GCIP loss independent of ON attacks in aquaporin4-antibody-seropositive NMOSD. Potential explanations for progressive GCIP thinning include primary retinopathy, drug-induced neurodegeneration and retrograde neuroaxonal degeneration from lesions or optic neuropathy. pRNFL thickening in the patients presenting with attacks during F/U might be indicative of pRNFL susceptibility to inflammation.

Keyphrases

drug induced
liver injury
oxidative stress
multiple sclerosis
single cell
cell therapy
adverse drug
human health
electronic health record