Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy.
Huan XuJunyi ChenZhi CaoXi ChenCaihong HuangJin JiYalong XuJunfeng JiangYue WangGuowang XuLina ZhouJingyi HeXuedong WeiJason Boyang WuZhong WangShancheng RenFu-Bo WangPublished in: Cancer biology & medicine (2022)
Blockade of pyruvate influx into mitochondria increased glycolysis levels in PCa but not in non-carcinoma prostate tissue. This transient blockage sensitized PCa to both detection and radiotherapy, thus indicating that glycolytic potential is a novel mechanism underlying PCa progression. The change in the mitochondrial pyruvate influx caused by transient MPC blockade provides a critical target for PCa diagnosis and treatment.
Keyphrases
- prostate cancer
- early stage
- loop mediated isothermal amplification
- locally advanced
- radical prostatectomy
- cell death
- radiation therapy
- label free
- cerebral ischemia
- real time pcr
- radiation induced
- oxidative stress
- reactive oxygen species
- human health
- induced apoptosis
- brain injury
- signaling pathway
- subarachnoid hemorrhage