Knockout of cardiolipin synthase disrupts postnatal cardiac development by inhibiting the maturation of mitochondrial cristae.

Mindong RenYang XuColin K L PhoonHediye Erdjument-BromageThomas A NeubertMichael Schlame

Published in: bioRxiv : the preprint server for biology (2023)

Cardiolipin is essential for the postnatal maturation of cardiomyocytes because it allows mitochondrial cristae to accumulate OXPHOS proteins to a high concentration and to shield them from degradation.

Keyphrases

preterm infants
oxidative stress
signaling pathway
heart failure