DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis.

David M HabielMiriam S N HohmannMilena S EspindolaAna Lucia CoelhoIsabelle JonesHeather JonesRichard CarnibellaIsaac PinarFreda WerdigerCory M Hogaboam

Published in: BMC pulmonary medicine (2019)

Together, our results show that the loss of DNA-PKcs promotes the expansion of SSEA4+ mesenchymal progenitors, and the senescence of their mesenchymal progeny.

Keyphrases

idiopathic pulmonary fibrosis
circulating tumor
bone marrow
cell free
stem cells
dna damage
single molecule
endothelial cells
interstitial lung disease
stress induced
signaling pathway
nucleic acid
rheumatoid arthritis