Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities.
Valérie BercierJeffrey M HubbardKevin FidelinKarine DuroureThomas O AuerCéline RevenuClaire WyartFilippo Del BenePublished in: Molecular neurodegeneration (2019)
Our study reveals a novel role for Dynactin1 in ALS pathogenesis, where it acts cell-autonomously to promote motor neuron synapse stability independently of dynein-mediated axonal transport.