Overexpression of GRK6 alleviates chronic visceral hypersensitivity through downregulation of P2Y6 receptors in anterior cingulate cortex of rats with prenatal maternal stress.

Yuan-Qing TianJia-Hui LiYong-Chang LiYu-Cheng XuPing-An ZhangQian WangRui LiGuang-Yin Xu

Published in: CNS neuroscience & therapeutics (2022)

These results indicate that decreased GRK6 leads to the accumulation of P2Y6 at neuron membrane in ACC, thereby contributing to visceral hypersensitivity of PMS rats.

Keyphrases

drug induced
cell proliferation
functional connectivity
insulin resistance
pregnant women
signaling pathway
type diabetes
birth weight
metabolic syndrome
mouse model
stress induced
weight gain