Antidepressant-like effect of dehydrozingerone from Zingiber officinale by elevating monoamines in brain: in silico and in vivo studies.

Sudheer MoorkothN Sai PrathyushaSuman ManandharYuanxin XueRunali SankheK S R PaiNitesh Kumar

Published in: Pharmacological reports : PR (2021)

DHZ demonstrated MAO-A inhibition in silico, and the increased neurotransmitter levels in the brain in vivo were associated with an antidepressant-like effect.

Keyphrases

major depressive disorder
resting state
white matter
molecular docking
functional connectivity
cerebral ischemia
bipolar disorder
multiple sclerosis
case control
brain injury
subarachnoid hemorrhage
molecular dynamics simulations