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Darolutamide Potentiates the Antitumor Efficacy of a PSMA-targeted Thorium-227 Conjugate by a Dual Mode of Action in Prostate Cancer Models.

Stefanie HammerAndreas SchlickerSabine Zitzmann-KolbeSimon BaumgartUrs B HagemannArne ScholzBernard HaendlerPascale LejeuneJenny KarlssonChristine EllingsenHartwig HennekesCarsten H NielsenMark U JuulDominik MumbergChristoph A Schatz
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
These results provide a strong rationale to investigate PSMA-TTC in combination with AR inhibitors in patients with prostate cancer.
Keyphrases
  • prostate cancer
  • pet ct
  • radical prostatectomy
  • pet imaging
  • cancer therapy
  • clinical trial
  • drug delivery
  • computed tomography
  • positron emission tomography