Ex-vivo expanded CD34 + cell transplantation alleviates fibrotic liver injury via innate immune modulation in metabolic dysfunction-associated steatohepatitis mice.
Atsutaka MasudaToru NakamuraHideki IwamotoHiroyuki SuzukiTakahiko SakaueToshimitsu TanakaYasuko ImamuraNobuyuki MoriHironori KogaTakumi KawaguchiPublished in: Cytotherapy (2024)
cells alleviate fibrotic liver injury in MASH mouse models through possible modulation of the innate immune response, which is abnormally activated by hepatocyte lipotoxicity.
Keyphrases
- liver injury
- immune response
- drug induced
- innate immune
- mouse model
- induced apoptosis
- systemic sclerosis
- cell therapy
- idiopathic pulmonary fibrosis
- cell cycle arrest
- single cell
- oxidative stress
- toll like receptor
- high fat diet induced
- type diabetes
- signaling pathway
- endoplasmic reticulum stress
- skeletal muscle
- nk cells
- inflammatory response
- metabolic syndrome
- wild type