Non-invasive detection of orthotopic human lung tumors by microRNA expression profiling of mouse exhaled breath condensates and exhaled extracellular vesicles.

Megan I MitchellIddo Z Ben-DovChristina LiuTao WangRachel B HazanThomas L BauerJohannes ZakrzewskiKathryn DonnellyKar ChowJunfeng MaOlivier Loudig

Published in: Extracellular vesicles and circulating nucleic acids (2024)

This study is the first of its kind and demonstrates that lung tumor EVs are exhaled in mice and provide non-invasive biomarkers for detection of lung tumors.

Keyphrases

loop mediated isothermal amplification
real time pcr
label free
genome wide
high fat diet induced
metabolic syndrome
dna methylation
transcription factor
wild type