DNA Tumor Viruses and Cell Metabolism.
Muhammad MushtaqSuhas DarekarElena KashubaPublished in: Oxidative medicine and cellular longevity (2016)
Viruses play an important role in cancerogenesis. It is estimated that approximately 20% of all cancers are linked to infectious agents. The viral genes modulate the physiological machinery of infected cells that lead to cell transformation and development of cancer. One of the important adoptive responses by the cancer cells is their metabolic change to cope up with continuous requirement of cell survival and proliferation. In this review we will focus on how DNA viruses alter the glucose metabolism of transformed cells. Tumor DNA viruses enhance "aerobic" glycolysis upon virus-induced cell transformation, supporting rapid cell proliferation and showing the Warburg effect. Moreover, viral proteins enhance glucose uptake and controls tumor microenvironment, promoting metastasizing of the tumor cells.
Keyphrases
- cell therapy
- single cell
- cell proliferation
- induced apoptosis
- circulating tumor
- cell cycle arrest
- single molecule
- sars cov
- metabolic syndrome
- papillary thyroid
- blood pressure
- type diabetes
- endothelial cells
- pi k akt
- mesenchymal stem cells
- young adults
- lymph node metastasis
- squamous cell
- childhood cancer
- sensitive detection
- genome wide identification